Az E3-on (vagyis előtte) leleplezték a Guitar Hero szeptember 1-jén megjelenő részének előadóit. A 85 zenekarból van jópár nagy név is.
- 3 Doors Down
- A Perfect Circle
- AFI
- Arctic Monkeys
- Attack! Attack!
- Band Of Horses
- Beastie Boys
- Beck
- Billy Idol
- Billy Squier
- Blink-182
- Blur
- Bob Dylan
- Bon Jovi
- Brand New
- Bush
- Children Of Bodom
- Coldplay
- Darker My Love
- Darkest Hour
- David Bowie
- Deep Purple
- Dire Straits
- Duran Duran
- Eagles Of Death Metal
- Elliott Smith
- Elton John
- Face To Face
- Garbage
- Gorillaz
- Gov't Mule
- Grand Funk Railroad
- Iggy Pop
- Iron Maiden
- Jeff Beck
- Jimmy Eat World
- John Mellencamp
- Johnny Cash
- Kaiser Chiefs
- King Crimson
- Kings Of Leon
- Kiss
- Love and Rockets
- Megadeth
- Mötley Crüe
- Muse
- My Morning Jacket
- Nirvana
- No Doubt
- Peter Frampton
- Public Enemy Featuring Zakk Wylde
- Queen & David Bowie
- Queens Of The Stone Age
- Rammstein
- Rose Hill Drive
- Rush
- Santana
- Scars On Broadway
- Screaming Trees
- Smashing Pumpkins
- Sonic Youth
- Spacehog
- Stevie Wonder
- Sublime
- Sunny Day Real Estate
- T. Rex
- The Bronx
- The Derek Trucks Band
- The Duke Spirit
- The Killers
- The Police
- The Raconteurs
- The Rolling Stones
- The Sword
- The White Stripes
- Thin Lizzy
- Thrice
- Tom Petty
- Tom Petty & The Heartbreakers
- TV On The Radio
- Vampire Weekend
- Weezer
- Wild Cherry
- Wolfmother
